Dr. Artinder Nagra and Dr. Stephen Barrett discuss Complex Regional Pain Syndrome (CRPS) on this episode of the Pod of Inquiry. This is an exciting opportunity to learn more about this debilitating condition and how it affects those who suffer from it. On this episode, you’ll hear from two leading experts in the field as they discuss its symptoms, diagnosis, treatments and potential future research directions for improving patient outcomes. They’ll also cover what we know about CRPS today and how our understanding has evolved over time. We hope you can join us for this important conversation!
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Show Notes from this episode
Dr. Nagra has recently completed fellowship training at the US Neuropathy Center in Marietta, GA under Drs. Barrett and DuCasse. She now heads up the US Neuropathy Center in Harrisburg, PA. She completed her Bachelor of Science (BS) in the Departmental Honors in Neuroscience at Indiana University. Her honors thesis was Subject processing in split ergativity: Neural benefits of case marking. Dr. Nagra then completed her Post Baccalaureate Certificate (PBC) in Biomedical Sciences & Professional Studies at Drexel University College of Medicine.
Dr. Barrett 01:06 Welcome Dr. Nagra
Dr. Nagra 04:07 The nomenclature of CRPS
Dr. Barrett 05:15 Most CRPS is Type II
Dr. Nagra 06:39 Who are the real idiots in idiopathic neuropathy and Type I CRPS?
Dr. Barrett 07:05 The discussion begins on this recent paper
The Role of Neuroinflammation in Complex Regional Pain Syndrome:Â A Comprehensive Review
Dr. Nagra 08:28 Keratinocytes and Neuro peptides
Dr. Barrett 11:08 Skin—The first tissue encountered in surgery
Dr. Nagra 12:44 Neurogenic inflammatory cascade that's going to be activating all these neuropeptides
Dr. Barrett 18:12 Keratinocytes stimulating glial cells?
Dr. Barrett 20:31 Activation of microglia and astrocytes was predominantly at the level of the initial injury, but extended throughout the spinal cord
Dr. Nagra 21:18 Discusses the inflammatory cascade of CRPS
Dr. Barrett 22:00 Falling dominoes
Dr. Barrett 24:00 The complex process of CRPS
Dr. Nagra 31:28 Acetone testing
Dr. Barrett 32:40 Exacerbating comorbidities of CRPS
Dr. Barrett 36:13 Pouring Gluten on the Fire
Dr. Nagra 37:09 Discusses Neuroplaticity
Dr. Barrett 38:03 The most inflammatory molecule? Sugar?
Dr. Nagra 39:40 Discusses Fasting
Dr. Barrett 40:10 His story of Fasting
Dr. Nagra 40:53 What about colon cleanse?
Dr. Barrett 41:06 The coffee enema?
Dr. Barrett 41:21 What the biohackers can teach you
Dr. Nagra 41:28 Are there varying levels of CRPS?
Dr. Barrett 42:02 there's a spectrum in my clinical experience
Dr. Nagra 44:23 Does it ever go away?
Dr. Barrett 44:51 Can it be cured?
Dr. Nagra 45:41 We have to keep getting updated
Dr. Barrett 46:32 What about future breakthroughs in treatment?
Dr. Nagra 48:46 Treatment is a team approach
Dr. Barrett 49:04 When the ship is sinking load the boat.
Dr. Barrett 50:09 Discusses the abyss between knowledge and clinical application
Dr. Nagra 50:46 Nerve is very complex
