We continue our last episodes discussion in this enlightening episode, where we dive deep into the world of cannabis with our special guest, Dr. Codi Peterson, PharmD. Dr. Peterson brings his extensive pharmaceutical knowledge and expertise to shed light on this complex and often misunderstood plant.
Episode Highlights:
- The science behind cannabis and its effects on the human body
- Medical applications and potential benefits of cannabis
- Addressing common misconceptions and myths
- The current state of cannabis research and future directions
- Responsible use and potential risks to consider
Whether you’re a medical professional, a curious consumer, or simply interested in learning more about this topical subject, this episode offers valuable insights for everyone.
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Show Notes from this episode
- Introduction and Overview of the Podcast 0:00
- Dr. Stephen Barrett welcomes listeners and introduces the continuation of his discussion with Dr. Codi Peterson, a professor at the University of California, Irvine.
- Dr. Peterson's expertise in cannabinoids and the endocannabinoid system is highlighted, emphasizing his work in education and advocacy.
- Dr. Peterson discusses the various cannabinoids, including THC, CBD, CBN, and others, and their therapeutic benefits based on preclinical and human studies.
- Understanding the Endocannabinoid System 2:53
- Dr. Peterson explains the concept of the endocannabinoid system, breaking down the term "endocannabinoid" to mean "from inside."
- He describes the system's role in maintaining homeostasis in all vertebrates, including humans, and its functions in relaxation, eating, sleeping, and protection.
- Dr. Barrett asks Dr. Peterson to define homeostasis, and Dr. Peterson explains it as the body's regulatory mechanism to maintain balance.
- Dr. Peterson elaborates on the endocannabinoid system's role in the body's response to its environment and its interaction with cortisol.
- Cannabinoids and Their Therapeutic Effects 6:14
- Dr. Peterson discusses the therapeutic benefits of various cannabinoids, including THC, CBD, CBN, and others, based on preclinical and human studies.
- He explains the endocannabinoid system's functions in the brain and immune system, highlighting the importance of CB1 and CB2 receptors.
- Dr. Peterson mentions the ubiquity of the endocannabinoid system in all vertebrates and some invertebrates, and its role in fine-tuning various functions.
- He describes the endocannabinoid system's involvement in the runner's high and its connection to the endorphin system.
- Terpenes and Their Role in Cannabis 18:37
- Dr. Peterson introduces the concept of terpenes, the aromatic compounds in cannabis and other plants, and their potential therapeutic effects.
- He explains the eight most common terpenes found in cannabis and their associated effects, such as myrcene, limonene, and linalool.
- Dr. Peterson discusses the historical use of terpenes in traditional medicine and their role in plant defense and communication.
- He highlights the endocannabinoid system's interaction with TRP ion channels and the expanded endocannabinoid system.
- Drug Delivery Methods and Their Challenges 29:15
- Dr. Peterson and Dr. Barrett discuss the various routes of drug delivery for cannabis, including topicals, enteral (oral), and inhalation (smoking, vaping, dabbing).
- They highlight the challenges associated with each route, such as variability in inhalation, inefficiency in smoking, and variability in oral ingestion.
- Dr. Peterson explains the limitations of topical administration and the lack of research on suppositories.
- They discuss the potential of sublingual administration and the benefits of trochees for faster absorption and consistent drug delivery.
- Conclusion and Future Discussions 43:58
- Dr. Barrett expresses his appreciation for Dr. Peterson's expertise and the comprehensive discussion on the endocannabinoid system.
- He mentions the potential for future discussions on psychedelics and their pharmacological effects.
- Dr. Peterson agrees and suggests an overview of psychedelics, including their historical use, differences, and therapeutic potential.
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