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Kenton Crowley

Kenton Crowley is a Diplomate of the American Academy of Anti-Aging Medicine. He received his Doctor of Pharmacy from University of California, San Francisco and completed his residency with Kaiser Permanente in Los Angeles, CA. He completed his Fellowship in Genomic, Metabolic and Nutritional Medicine in 2011. Dr. Crowley currently is the Chief Medical Officer for Farm to Farma Inc. in Reno, NV., the Patient Care Corp. in Huntington Beach, CA. and President of Crowley Consultants Inc. in Temecula, CA. He is an expert in Lifestyle Medicine, working with patients & physicians incorporating cannabis in disease state treatment and symptoms management, whether as a primary treatment or complementary to traditional and/or other modalities.

Gavin Chandler

Gavin Chandler is the Chief Executive Officer of Trokie, a position he has held since October 2021. Gavin builds enterprise value in early and mid-stage companies in diverse fields by leveraging his broad skills for business development, financial innovation, team building, and operations. Gavin has held executive roles in diverse fields including biotechnology, energy, big data, real estate services, and transportation safety. He’s also co-authored patents and managed patent prosecution in the fields of vehicle safety, gaming, biotechnology, environmental engineering, and genomics.

Gavin earned his B.S. in Biochemistry, Cum Laude, from the University of Nevada. He received his formal training in finance through the CFA program, earning his CFA Charter in 2007. Gavin has been a Board member of the CFA Society of Nevada since 2014. Gavin lives with his wife and daughter in Reno, Nevada.

• Introduction to Trokie and Its Founders 0:06
  • Dr. Barrett introduces the episode and the special guests, Dr. Kenton Crawley (Chief Medical Officer) and Gavin Chandler (CEO) of Trokie.
  • Dr. Barrett mentions Trokie as a prominent sponsor of the show and expresses excitement about their work.
  • Gavin Chandler explains that Trokie is a dietary supplements company specializing in phytocannabinoids and novel delivery systems for healthcare professionals and their patients.
  • Gavin emphasizes their commitment to rigorous testing and scientific methods to help patients achieve their health goals.
• Dr. Barrett’s N of One Study and Personal Experience 3:04
  • Dr. Barrett discusses his N of one study, where he tested Trokie’s product for sleep and calming effects.
  • He shares his experience of optimizing patients’ metabolic and overall health to improve the outcomes of peripheral nerve surgery.
  • Dr. Barrett highlights the importance of considering the patient as a whole individual rather than just focusing on the peripheral nerve entrapment.
  • He introduces the concept of homeostasis and its role in maintaining physiologic balance.
• Exploring the Endocannabinoid System 6:14
  • Dr. Barrett and Dr. Kenton Crawley delve into the endocannabinoid system, its discovery, and its role in regulating homeostasis.
  • Dr. Crawley explains that the endocannabinoid system is involved in various physiologic processes, including appetite, metabolism, and immune function.
  • They discuss the importance of the endocannabinoid system in stress, diet, exercise, and sleep.
  • Dr. Crawley mentions that the endocannabinoid system was recognized in the recent decade as a crucial regulator of homeostasis.
• Phytocannabinoids and Their Impact on Health 15:12
  • Gavin Chandler talks about the increasing interest in the endocannabinoid system among clinicians and academic scientists.
  • He highlights the diversity of phytocannabinoids and their presence in various organisms, including insects and plants.
  • Gavin explains that the endocannabinoid system acts as a fine-tuning system, affecting various physiologic responses.
  • Dr. Barrett and Dr. Crawley discuss the potential downregulation of the endocannabinoid system due to stress, diet, and other factors.
• Receptors and Phytocannabinoids 15:28
  • Dr. Crawley explains the ubiquitous presence of cannabinoid receptors in the body, including CB1 and CB2 receptors.
  • He mentions other receptors like GRP55 and their role in regulating various physiologic processes.
  • Gavin Chandler discusses the complex signaling patterns of the endocannabinoid system and its impact on metabolic pathways.
  • They emphasize the importance of understanding the endocannabinoid system to develop effective therapeutic strategies.
• Differences Between Cannabis Sativa and Indica 20:11
  • Dr. Crawley clarifies that the terms “sativa” and “Indica” are more descriptive of the plant’s appearance and effects rather than its chemical composition.
  • He explains that the same cannabis plant can be cultivated differently to produce sativa or Indica effects.
  • Dr. Barrett draws a parallel to viticulture, where the same grape variety can produce different wines depending on its cultivation.
  • They discuss the importance of understanding the cannabinoid and terpene profiles of different cannabis strains.
• Delivery Systems and Bioavailability 34:03
  • Dr. Crawley outlines various routes of administration for cannabis, including smoking, vaping, edibles, and sublingual administration.
  • He explains the differences in bioavailability and onset of action between these delivery methods.
  • Dr. Barrett emphasizes the importance of choosing the right delivery method to ensure efficacy and avoid adverse effects.
  • Gavin Chandler discusses the challenges of dosing with edibles and the preference for non-inhalation methods among clinicians.
• Trokie’s Unique Delivery System 43:20
  • Dr. Crawley explains how Trokie’s lozenges (troches) offer improved bioavailability and faster onset of action compared to other delivery methods.
  • He describes the process of placing the troche between the cheek and gum to minimize saliva production and enhance absorption.
  • Dr. Barrett highlights the benefits of Trokie’s delivery system for patients who prefer non-inhalation methods.
  • Gavin Chandler discusses the importance of consistent dosing and the challenges of titrating doses with other delivery methods.
• Clinical Applications and Patient Support 43:37
  • Gavin Chandler outlines the tools and programs Trokie provides to support clinicians and their patients, including custom landing pages and educational content.
  • He explains the Trokie Tracker assessment tool, which helps patients and clinicians track wellness goals over time.
  • Dr. Barrett appreciates the robust tracking and data feedback provided by Trokie’s tools.
  • Gavin mentions the special pricing for patients and clinicians affiliated with Trokie’s network.
• Conclusion and Call to Action 51:52
  • Dr. Barrett concludes the episode, emphasizing the importance of the discussion and the benefits of Trokie’s products.
  • He announces that the episode will be divided into two parts and encourages listeners to tune in for the next week’s continuation.
  • Gavin Chandler provides instructions on how to enroll in Trokie’s wellness program and access special pricing.
  • Dr. Barrett thanks the guests and listeners, and promotes the sponsor’s products, emphasizing their importance in health and wellness.