We’re thrilled to announce our latest episode featuring Dr. Jason R. Williams, a true pioneer in the field of immunotherapy and cancer treatment innovation.
Dr. Williams, a board-certified radiologist and image-guided cancer specialist, shares his revolutionary journey in developing intra-tumoral interventions that are changing how we approach cancer treatment. As the physician who performed the world’s first ablation procedure combined with immunotherapy agents, his work represents one of the most exciting frontiers in medicine today.
What You’ll Discover:
- The science behind using ablation as an immunotherapy agent
- How intra-tumoral interventions are revolutionizing cancer treatment
- Insights from thousands of procedures, many “first in human”
- The future of cryoablation therapies and personalized cancer treatment
- Real patient success stories and outcomes
- Intra-Tumoral Cancer Treatments
Also available on
Guest Biography
Dr. Jason R. Williams
Jason R. Williams is a medical doctor, board-certified radiologist, image-guided cancer specialist, researcher, and professor. He is one of the pioneers of immunotherapy, specializing in intra-tumoral interventions. He performed the world’s first ablation procedure and implemented an intra-tumoral injection of a specific combination of immunotherapy agents, thus leveraging the actual process of ablation as an immunotherapy agent itself. Since then, he has performed thousands of procedures many of them “first in human” in multiple areas of ablation and cryoablation therapies.
Dr. Williams is the Director of Interventional Oncology and Immunotherapy at the Williams Cancer Institute, where he has been advancing the use of intra-tumoral immunotherapy. He is also an adjunct professor at Case Western Reserve University in Cleveland, Ohio, where he is helping to further cutting-edge research. In addition, he is actively involved in private research combining numerous different immunotherapy agents for image-guided intra-tumoral injection covering almost all cancer types. To learn more about Dr. Williams and his clinic, visit www.WilliamsCancerInstitute.com.
Dr Williams started doing ablation in the early 2000s in his university. Then the need of creating an institute started to become more evident, but the process was not easy. Williams Cancer Institute started in a difficult time because there was lack of approval, lack of insurance coverage and the hospitals were not receptive. In 2014, we started doing procedures mainly in the US. Our facilities were in Florida, Atlanta and lately in Southern California where we then decided to move to Mexico and eventually, to Mexico City. Williams Cancer Institute was called Image Guided Cancer Specialist at that moment. It was at the same time when Dr. Williams was writing our book The Immunotherapy Revolution. It ultimately changed to Williams Cancer Institute and now we have 3 facilities in between Mexico and the US, having the best team ready to save cancer patients’ lives. We´re also looking to keep growing and we hope to get more facilities around the world, someday we want to achieve the dream of Dr. Williams to see cancer become a distant memory from the past.
Show Notes from this episode
- Introduction and Guest Background 0:00
- Dr. Barrett introduces Dr. Jason Williams, Director of the Williams Cancer Institute and a board-certified radiologist.
- Dr. Barrett highlights Dr. Williams’ pioneering work in ablative procedures for solid mass tumors, which is shifting the paradigm of traditional oncology.
- Dr. Barrett encourages listeners to visit Dr. Williams’ YouTube videos and website for more information.
- Dr. Barrett expresses excitement about the potential life-changing impact of the conversation.
- Dr. Williams’ Journey and Passion for Cancer Treatment 0:48
- Dr. Barrett asks Dr. Williams about his passion for cancer treatment and how it developed.
- Dr. Williams explains his initial confusion about why patients with cancer were not being treated directly by injecting drugs into the tumor.
- Dr. Williams shares his research experience in college, where injecting tumors in animals showed good results, but human studies with intravenous or oral therapies failed.
- Dr. Williams describes his realization during medical school that interventional radiologists were already injecting medications into tumors, leading him to focus on radiology and immunotherapy.
- Innovative Treatment Techniques and Ablation 4:10
- Dr. Barrett asks Dr. Williams about his pioneering work in ablation for intra-tumoral therapy.
- Dr. Williams discusses a patient with four lesions in his lung, where treating two lesions led to the spontaneous regression of the untreated lesions.
- Dr. Williams explains the concept of the abscopal effect, where treating one tumor can lead to the regression of untreated tumors.
- Dr. Williams describes the evolution of ablation technologies, including cryoablation, radiofrequency, and pulse electric field (PEF), and their impact on immune stimulation.
- Immune Response and Technological Evolution 7:37
- Dr. Barrett inquires about the primary factor in Dr. Williams’ evolution from cryo to radiofrequency and PEF.
- Dr. Williams explains the focus on enhancing the immune response and the development of PEF technology, which has FDA approval for about two and a half years.
- Dr. Williams discusses the differences between PEF, cryoablation, and other ablation techniques in terms of immune stimulation and tissue damage.
- Dr. Williams emphasizes the importance of leaving some tumor tissue intact to stimulate an immune response.
- Challenges and Advancements in Cancer Treatment 20:08
- Dr. Barrett and Dr. Williams discuss the challenges of changing the paradigm of traditional oncology.
- Dr. Williams highlights the importance of treating tumors directly and the potential benefits of intra-tumoral injections of agents like vitamin C and ivermectin.
- Dr. Williams explains the cost and adverse event benefits of using less expensive agents to boost the immune response.
- Dr. Williams emphasizes the need for a minimally invasive approach to cancer treatment to preserve patients’ quality of life.
- Gut Microbiome and Optimizing Human Health 27:31
- Dr. Barrett asks Dr. Williams about the importance of the gut microbiome in cancer treatment.
- Dr. Williams discusses the impact of antibiotics and artificial sweeteners on the gut microbiome and the use of supplements like navy beans to optimize it.
- Dr. Williams explains the role of the gut microbiome in immunotherapy and the potential benefits of fecal transplants and Rebyota
- Dr. Williams highlights the importance of maintaining a healthy gut microbiome to enhance the effectiveness of cancer treatments.
- Clinical Trials and Global Reach 32:52
- Dr. Barrett inquires about the availability of Dr. Williams’ treatments and clinical trials.
- Dr. Williams mentions his offices in Beverly Hills, Cabo San Lucas, Mexico, Mexico City, and Miami, and the availability of clinical trials in the United States.
- Dr. Williams explains the benefits of treating patients outside the US due to cost and regulatory differences.
- Dr. Williams discusses the importance of clinical trials in establishing the effectiveness of new treatments and the challenges of obtaining insurance coverage.
- Innovative Techniques and Future Directions 36:41
- Dr. Barrett asks Dr. Williams about the use of liquid biopsies and early cancer detection methods.
- Dr. Williams discusses the potential benefits of liquid biopsies for diagnosis and early detection of cancer.
- Dr. Williams explains the use of whole-body MRIs and other imaging techniques for cancer detection.
- Dr. Williams highlights the importance of minimally invasive techniques and the potential use of robotic guidance in cancer treatment.
- Quality of Life and Patient Experience 44:46
- Dr. Barrett and Dr. Williams discuss the importance of preserving patients’ quality of life during cancer treatment.
- Dr. Williams emphasizes the need for treatments that do not involve major surgery or chemotherapy, which can damage patients’ immune systems.
- Dr. Williams explains the benefits of minimally invasive techniques and the use of lighter anesthesia to preserve the immune response.
- Dr. Williams highlights the importance of treating cancer patients in a way that allows them to maintain their quality of life and avoid long-term damage.
- Conclusion and Future Prospects 52:10
- Dr. Barrett thanks Dr. Williams for his contributions to the field of cancer treatment and the potential impact of his work.
- Dr. Williams discusses the ongoing research and clinical trials aimed at improving cancer treatment and enhancing patients’ quality of life.
- Dr. Williams highlights the importance of continued innovation and collaboration in the field of cancer treatment.
- Dr. Barrett encourages listeners to explore Dr. Williams’ work and consider the potential benefits of minimally invasive cancer treatments.
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