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Dr. Bill Lawrence, PhD

Dr. Lawrence, an American biogerontologist, brings a unique blend of qualifications to his research. His Jurisprudence Degree (UCLA-Law) provides a unique legal research perspective to his work, his MS in Psychology offers insights into human behavior and cognition, and his Ph.D. in Nutritional Science equips him with a deep understanding of the biological processes of aging. This multidisciplinary approach allows him to view aging from various angles, enhancing his ability to develop comprehensive solutions. Over three decades, he has applied this approach to focus on human longevity research and interventions for optimal life and health span.

Dr. Lawrence is affiliated with the St. Petersburg Institute of Bioregulation and Gerontology (Russia), a hub of pioneering research in biogerontology. He is the administrator of two groundbreaking Russian and American longevity clinical studies: Telomerase activation and DNA/Methylation Epigenetic Age Modification, which are at the forefront of longevity research. These studies and the significant results promise to revolutionize our understanding of the aging process and longevity interventions.

At age 78, Dr. Lawrence’s research has profoundly slowed his aging process, enhancing his potential longevity and health span, as well as that of 150 clinical study participants, primarily physicians. His average telomere length, or “Cellular Age,” is equivalent to that of a 23-year-old. His “Epigenetic Age,” measured by the Horvath Epigenetic Clock (DNA/Methylation), is ten years less than his chronological age, resulting in a fifty percent reduction of all-cause mortality risk compared to his same-age peers. His annual biological rate of aging at 79% is twenty-one percent slower than his chronological yearly aging, a personal testament to the power of his research.

Today, he will present data and evidence proving that the primary cause of aging is the degradation of the cellular DNA Repair System. He will then confirm that Peptide Bioregulators, a groundbreaking development by Prof. Vladimir Khavinson of the St. Petersburg Institute, is the intervention that restores the DNA Repair System via cellular reprogramming, tissue rejuvenation, and organ regeneration. The result is enhanced longevity and health span.

• Telomere Age and Longevity Studies 0:00
  • Dr. Barrett introduces the episode, focusing on longevity, morbidity, and mortality studies from Dr. Khavinson’s research in St. Petersburg, Russia.
  • Dr. Lawrence shares a case study of his wife who had slightly accelerated telomere age at 63 but improved to the telomeres of a 33-year-old after using peptides.
  • Her telomere age was equivalent to a 49-year-old two years later, demonstrating significant telomere lengthening.
  • Dr. Lawrence discusses various participants’ telomere age reductions, noting that higher dosage protocols did not necessarily lead to more telomere extension.
• Stress and Telomere Acceleration 4:32
  • Dr. Lawrence explains the relationship between stress and telomere acceleration, using a bar chart to illustrate the results of the clinical study.
  • The study showed an average telomere extension of almost 22 years over three years, which is unusual as telomeres typically shorten with each cell replication.
  • The study also included an epigenetic methylation study to investigate the impact of peptides on gene expression related to longevity.
  • Dr. Lawrence describes the concept of epigenetics, which involves turning on and off certain genes related to longevity without altering the DNA.
• Epigenetic Methylation Study 6:31
  • Dr. Lawrence discusses the epigenetic methylation study, which aimed to use peptides to influence gene expression favorably.
  • The study measured genes that were turned off or on, focusing on those related to longevity.
  • Dr. Lawrence references a book by Khavinson and other scientists on the epigenetic control of aging, which supports the use of peptides for epigenetic regulation.
  • The study demonstrated that peptides can dock onto the major groove of DNA, influencing DNA methylation and turning on and off certain genes.
• Biological Aging and Mortality Risk 9:27
  • Dr. Lawrence explains the concept of biological aging and how it can be estimated using the Horvath clock at UCLA.
  • The study found that each year of epigenetic age above chronological age increases the risk of cancer and mortality.
  • Dr. Lawrence provides a graphic to illustrate the relationship between epigenetic age and mortality risk, showing significant increases in mortality risk with each year of epigenetic aging.
  • The study also showed that reducing epigenetic age can significantly decrease all-cause mortality risk.
• Case Studies of Epigenetic Age Reduction 13:08
  • Dr. Lawrence shares case studies of individuals who experienced significant reductions in epigenetic age after using peptides.
  • One individual’s DNA age was reduced from two years older to less than their chronological age, resulting in a decreased all-cause mortality risk.
  • Another individual, Connie, had an excellent baseline of being eight years younger epigenetically but further reduced her epigenetic age by two years.
  • Dr. Lawrence discusses the importance of measuring epigenetic age to determine the pace of aging and create personalized protocols for longevity.
• Organ-Specific Epigenetic Age 24:37
  • Dr. Lawrence explains how the testing has advanced to assess the epigenetic age of specific organs and systems.
  • The study showed that focusing on organs and systems that are aging faster can help create more precise protocols for longevity.
  • Dr. Lawrence provides an example of a person whose liver age was 59, brain age was 61, but metabolic age was 69, indicating areas for improvement.
  • The study demonstrated a 4.767% improvement in epigenetic age over two years, translating into a 56% decrease in all-cause mortality.
• Mortality Reduction Studies 28:54
  • Dr. Lawrence references a study by Khavinson that showed significant reductions in mortality rates with the use of peptides.
  • The study included elderly people (60-74 years old) and older people (75-89 years old), with significant reductions in mortality rates when using peptides.
  • The study also showed a significant reduction in morbidity, particularly respiratory diseases, in a group of 11,000 people.
  • Dr. Lawrence discusses the Hayflick limit, which measures the number of times a cell can divide, and how peptides can increase this limit.
• Retinal Disease Treatment 36:48
  • Dr. Lawrence shares studies from Khavinson’s vision clinic in St. Petersburg, which treats retinal diseases using peptides.
  • The clinic has treated patients from all over the world, showing significant improvements in vision for conditions like diabetic retinopathy and age-related macular degeneration.
  • Dr. Lawrence provides examples of before and after retinal scans, showing dramatic improvements in vision after treatment with peptides.
  • The study also includes cases of retinitis pigmentosa, an inherited disease, where peptides have significantly improved vision and quality of life.
• The Bridge to Future Longevity Interventions 41:55
  • Dr. Lawrence discusses the concept of the “bridge,” which involves using current interventions like peptides to stay healthy and take advantage of future longevity interventions.
  • The bridge includes various interventions like stem cells, artificial intelligence, CRISPR, and organ replacement.
  • Dr. Lawrence emphasizes the importance of staying healthy to benefit from future advancements in longevity research.
  • The study shows that peptides are a powerful intervention for longevity and can significantly improve health and reduce mortality risk.
• Conclusion and Future Directions 46:00
  • Dr. Lawrence concludes by discussing the creation of a peptide longevity protocol based on the extensive data from the studies.
  • The protocol aims to enhance longevity by using peptides and other interventions to improve health and reduce mortality risk.
  • Dr. Barrett thanks Dr. Lawrence for sharing the fascinating research and emphasizes the importance of data in supporting the findings.

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