We’re thrilled to announce our latest episode featuring a true pioneer in Alzheimer’s research:
“Reversing Alzheimer’s: Dr. Dale Bredesen’s Groundbreaking Approach to Cognitive Decline”
Dr. Dale Bredesen, author of the revolutionary book “The End of Alzheimer’s,” joins us to discuss:
- His innovative protocol for preventing and reversing cognitive decline
- The latest breakthroughs in Alzheimer’s research
- Practical steps you can take to protect your brain health
Don’t miss this potentially life-changing episode. Available now on all major podcast platforms.
Listen, learn, and take control of your cognitive health!
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Show Notes from this episode
Books by Dr. Dale Bredesen
Dr. Bredesen graduated from Caltech and received his MD from Duke.  He trained with Nobel laureate Prof. Stanley Prusiner, and was the Founding President of the Buck Institute for Research on Aging. His research led to over 230 published papers, and the first reversal of cognitive decline in patients with Alzheimer’s disease, using a precision medicine protocol. He is the author of two New York Times best sellers, and is Senior Director of the world’s first precision medicine program for neurodegenerative diseases, at the Pacific Neuroscience Institute.
Summary
- Starting the Pod of Inquiry Season Five 0:00
- Dr. Barrett welcomes listeners to the 105th episode and the start of season five, expressing gratitude for their support and curiosity.
- He highlights the journey from biohacking to exploring topics with world-class experts and best-selling authors.
- Dr. Barrett emphasizes the importance of asking the right questions rather than having all the answers.
- He expresses excitement for future episodes and the honor of having world-class experts seeking to share their expertise.
- Introduction to Dr. Dale Bredesen 2:11
- Dr. Barrett introduces Dr. Dale Bredesen, a pioneer in Alzheimer's research and treatment, and author of "The End of Alzheimer's."
- He highlights Dr. Bredesen's unique position as both a clinician and bench scientist, revolutionizing the understanding of Alzheimer's disease.
- Dr. Bredesen's research focuses on the role of amyloid beta and its precursor protein, challenging the traditional one-disease, one-drug approach.
- Dr. Bredesen's comprehensive, personalized treatment protocol, the Recode program, addresses multiple factors contributing to cognitive decline.
- Dr. Bredesen's Background and Translational Medicine 4:12
- Dr. Bredesen shares his background, including his training at Caltech, Duke, and UCSF, and his interest in degenerative diseases.
- He discusses the lack of therapeutic success in degenerative diseases and the need for better understanding of their causes.
- Dr. Bredesen explains the importance of translational medicine and the interplay between bedside and bench research.
- He highlights the significance of lifestyle factors, nutrition, and addressing various holes in the roof that can lead to Alzheimer's disease.
- Understanding Amyloid Beta and Its Role in Alzheimer's 8:22
- Dr. Bredesen explains the physiology of amyloid beta and its precursor protein, emphasizing their roles in connection and protection.
- He discusses the evolutionary selection for performance over durability and its impact on neurodegeneration.
- Dr. Bredesen describes the switch from connection to protection mode in the brain and its implications for Alzheimer's disease.
- He highlights the importance of understanding the molecular pathways involved in neuroplasticity and Alzheimer's prevention.
- The Recode Program and Precision Medicine 29:30
- Dr. Bredesen introduces the Recode program, a comprehensive approach to Alzheimer's prevention and treatment.
- He explains the seven basics of the program: diet, exercise, sleep, stress, brain training, detox, and targeted supplements.
- Dr. Bredesen discusses the importance of addressing chronic infections, toxins, and other factors that contribute to Alzheimer's risk.
- He emphasizes the need for personalized medicine and the role of functional medicine in treating Alzheimer's.
- Challenges and Future of Alzheimer's Research 56:05
- Dr. Bredesen discusses the challenges in changing the paradigm of Alzheimer's research and the resistance from mainstream medicine.
- He highlights the importance of precision medicine and the need for a network-based approach to treating Alzheimer's.
- Dr. Bredesen shares his experiences with successful clinical trials and the potential for personalized treatment protocols.
- He emphasizes the importance of early prevention and the role of genetic testing in identifying Alzheimer's risk.
- The Role of Functional Medicine in Alzheimer's Treatment 56:34
- Dr. Bredesen explains the influence of his wife, a functional medicine doctor, on his approach to Alzheimer's research.
- He discusses the integration of functional medicine tools and approaches into the Recode program.
- Dr. Bredesen highlights the importance of addressing upstream causes of Alzheimer's, such as inflammation, stress, and nutritional deficiencies.
- He shares success stories of patients who have improved with the Recode program and the importance of a multimodal approach.
- The Future of Alzheimer's Prevention and Treatment 56:52
- Dr. Bredesen discusses the potential for early detection and prevention of Alzheimer's through cognitive assessments and biomarker testing.
- He emphasizes the importance of addressing lifestyle factors and environmental toxins to reduce Alzheimer's risk.
- Dr. Bredesen highlights the need for a paradigm shift in Alzheimer's research and the potential for personalized treatment protocols.
- He shares his vision for a future where Alzheimer's is rapidly becoming optional through early prevention and targeted interventions.
- The Importance of Early Prevention and Genetic Testing 57:09
- Dr. Bredesen discusses the importance of early prevention and the role of genetic testing in identifying Alzheimer's risk.
- He emphasizes the need for regular cognitive assessments and biomarker testing to detect Alzheimer's early.
- Dr. Bredesen highlights the potential for personalized treatment protocols based on genetic and lifestyle factors.
- He shares his vision for a future where Alzheimer's is rapidly becoming optional through early prevention and targeted interventions.
- The Role of Compassionate Use in Alzheimer's Treatment 57:28
- Dr. Bredesen discusses the concept of compassionate use in Alzheimer's treatment and the importance of making effective treatments available.
- He shares examples of successful treatments and the potential for personalized treatment protocols.
- Dr. Bredesen emphasizes the importance of early intervention and the role of compassionate use in improving patient outcomes.
- He highlights the need for a paradigm shift in Alzheimer's research and the potential for personalized treatment protocols.
- The Impact of the Recode Program on Patient Outcomes 1:05:39
- Dr. Bredesen shares success stories of patients who have improved with the Recode program and the importance of early intervention.
- He emphasizes the need for a multimodal approach to treating Alzheimer's and the potential for personalized treatment protocols.
- Dr. Bredesen highlights the importance of addressing lifestyle factors and environmental toxins to reduce Alzheimer's risk.
- He shares his vision for a future where Alzheimer's is rapidly becoming optional through early prevention and targeted interventions.
