What if restoring your gut bacteria could rival chemotherapy—without the devastating side effects?
In this groundbreaking episode of Pod of Inquiry, Dr. Nathan Goodyear reveals how the gut microbiome, fecal transplants, and intratumoral therapies are reshaping the future of cancer treatment. (Fecal Transplants for Cancer Treatment)
Dr. Goodyear, Medical Director at the Williams Cancer Institute, shares cutting-edge research that challenges everything we think we know about cancer, immunity, and modern oncology.
What You’ll Learn in This Episode:
- Why 25% of 2-year-olds have zero beneficial gut bacteria—and how this ties into rising cancer rates
- How fecal microbiota transplants (FMT) are turning non-responders into immunotherapy responders
- The shocking way chemotherapy creates cell senescence, potentially sabotaging long-term immunity
- The cancer-parasite debate finally explained—what ivermectin & fenbendazole can and cannot do
- How traditional biopsies may spread cancer, and why intratumoral therapy is a paradigm shift
- The 53% “no evidence of disease” rate Dr. Goodyear achieved in Stage 4 prostate cancer patients
- Why these advanced treatments are happening in pristine facilities in Cabo, Mexico—and not the U.S.
The current “war on cancer” is failing—and younger people are getting sick at alarming rates. This episode breaks down why aging and cancer are fundamentally connected, why trust in medicine is collapsing, and what you can do right now to protect yourself and your loved ones.
If you’re dealing with cancer, supporting someone who is, or trying to prevent it—this may be the most important conversation you hear this year.
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Guest Biography
Dr. Nathan Goodyear, MD, MD(H), ABAARM, FMNM
Dr. Goodyear, an established authority in integrative oncology, possesses extensive knowledge. He earned his Bachelor of Arts from Louisiana Tech University and his Doctor of Medicine from LSU Health Sciences Center. He is Board-Certified in Obstetrics and Gynecology and held the position of Chief Resident in Obstetrics and Gynecology at the University of Tennessee. His primary practice focus in Obstetrics and Gynecology was in the area of pelvic floor surgery. Dr. Goodyear is a Fellow in Functional and Regenerative Medicine. Dr. Goodyear has served as the medical director for two successful integrative cancer clinics in the Phoenix area for the last seven years. He joined the Williams Cancer Institute team in May 2024 to focus on innovation in the cancer field to elevate and empower patients and physicians.
Dr. Goodyear holds licensure from the Arizona and California Medical Boards and the Arizona Homeopathic and Integrative Medical Board. Dr. Goodyear has been active in the Integrative Medicine movement since 2006 and has delivered nationwide presentations on diverse topics. He is a highly sought-after speaker and podcaster regarding high-dose IV vitamin C, vitamin C stacking therapies, Precision Therapy Stacking, medical cannabis in oncology, Low-Dose Metronomic Chemotherapy (LDMC), Insulin Potentiated Therapy (IPT), hyperthermia, and various other natural, holistic, and integrative approaches in cancer treatment. He has engaged in worldwide collaboration and instruction on high-dose intravenous vitamin C and vitamin C stacking therapies for treating SARS-CoV-2 and cancer.
Dr. Goodyear is an accomplished writer and published author of three books, including the most recent, “Breaking the Cancer Code: 7 Next-Gen Integrative Oncology Therapies.” He is an avid blogger on docgoodyear.com, pre-scribed.com, and off-scriptRx.com. He is passionate about connecting with patients and physicians through his podcasts “Pre-scribed by Dr. Nathan Goodyear” and “Off-ScriptRx.” Additionally, he was featured in the book “BOLD Mission, Courageously Pursue Your Calling,” authored by international speaker Debra Boblitt. He regularly appeared as a guest on the prominent nationally syndicated health radio program, the Doctor Bob Martin Show, and was featured on the Mercola podcast discussing high-dose vitamin C in cancer treatment. Dr. Goodyear’s commitment to patient advocacy is unwavering. He is not just a thought leader, a passionate entrepreneur, and a pioneer in integrative medicine; he is also a fervent advocate for his patients, ensuring their voices are heard and their needs are met.
Show Notes from this episode
01:17 – Opening Discussion
- Dr. Barrett thanks Dr. Goodyear for returning to the show
- Discussion about the importance of asking questions and critical thinking in medicine
- Dr. Goodyear emphasizes that questions are discouraged in modern medical practice, which favors conformity over critical thinking
02:35 – Williams Cancer Institute’s Work
- Discussion of the extensive research and innovative approaches at Williams Cancer Institute
- Dr. Goodyear explains they’re “crushing the old paradigm” with new therapeutics
- Need to reprogram both cancer and the minds of doctors, scientists, and the public
03:17 – Paradigm Shifts in Medicine
- Current era compared to major historical scientific shifts (Pythagoras, Copernicus)
- Discussion of resistance to new ideas and potential for “cancelation” on social media
- Commitment to pushing forward despite opposition
04:39 – The New Book
- Dr. Goodyear announces a forthcoming book (title still in development, expected early 2026)
- Central thesis: Aging and cancer are one and the same
- Proposes treating both simultaneously by targeting the tumor while healing the body
- Challenges the 100-year “warfare” mentality in cancer treatment (chemotherapy, surgery, radiation)
- Introduces concept of cell senescence and its role in accelerating aging and disease
08:26 – Gut Microbiome and Immune System
- Introduction of the “gut-immune-brain axis” (emphasis on gut-immune connection in cancer)
- Case study progression: C-section birth → lack of breastfeeding → antibiotic use → obesity → cancer
- Immune surveillance begins with vaginal birth and breastfeeding
10:00 – The My Baby Biome Study
- Critical findings from 7-year study of children aged 3-7 months
- 25% of children at 2 years had complete extinction of Bifidobacterium
- 87% had significantly depleted beneficial bacteria
- Implications for compromised immune system and increased cancer risk
14:08 – Fecal Transplantation Research
- Current research: retrospective studies on fecal transplant in cancer patients
- Previous research showed non-responders to immunotherapy became responders after fecal transplant from responders
- Williams Cancer Institute gives fecal transplants to majority of cancer patients due to compromised gut microbiome
- Goal: determine if patients outlive standard of care overall survival rates
15:00 – Future of Fecal Transplantation
- Moving toward precise, customized fecal transplantation for both treatment and prevention
- Future will include altering treatments based on gut microbiome RNA/DNA testing
- Currently one FDA-approved fecal transplant product (for C. difficile after two failed antibiotic treatments)
20:00 – Administration and Mechanisms
- Fecal transplant involves transferring microbiome bacteria and metabolites from donor to recipient
- Currently administered as enema (live biological organism requiring careful handling)
- Concerns about oral administration potentially causing off-target colonization
- Critical concept: bacteria must engraft (like organ transplants)
- Process reduces dysbiosis and systemic inflammation
23:00 – Preventative Applications
- Potential to intervene early in children born by C-section who weren’t breastfed
- Could restore Bifidobacterium and protect against future disease
- Vision for customized transplants based on family disease history
25:00 – Chemotherapy and the Gut
- Chemotherapy has detrimental effects on gut microbiome
- Discussion of “warfare” approach to cancer treatment
25:38 – Cell Senescence Explanation
- Surgery, chemotherapy, and radiation all promote cell senescence
- Cell senescence = cells stop replicating but remain metabolically active
- Senescent cells produce inflammatory cytokines, chemokines, and growth factors
- Can reactivate and promote other healthy cells to become senescent
- Aging associated with accumulation of senescent cells
- Recent studies (2021, 2024) show cell senescence drives chemotherapy-induced peripheral neuropathy
30:00 – Intratumoral Approaches
- Williams Cancer Institute specializes in targeting tumors directly rather than systemic warfare
- Concept: “Why can’t we treat when we biopsy?”
- Example: DCIS breast cancer – biopsy, treat immediately with cryoablation and immunotherapy
- Advantage: engages immune system immediately, no delay in treatment
- Addresses concern that biopsy can cause metastasis
35:00 – Radiation Paradox
- Radiation causes cancer (Chernobyl, Hiroshima, Nagasaki) yet is used to treat cancer
- Tumor bed effect: radiation of tumor bed decreases local recurrence but sets up potential for distant spread
- Radiation induces amphiregulin release, which compromises immune system at distant metastatic sites
- Radiation alters bystander cells, pushing them into senescence and accelerating aging
36:31 – The Business of Medicine
- Discussion of financial considerations in oncology
- Reimbursement structure for chemotherapy infiltrations
- Description of problematic business model:
- Control the environment creating disease
- Control products causing disease
- Control products treating disease
- Control regulatory access
- Result: “perfect business model” where patients are the commodity
40:00 – Patient Trust Crisis
- 2024 JAMA survey: only 40% of patients trust doctors and hospitals (one of lowest on record)
- Need for physicians to speak truth even when not accepted
- Importance of leading with science and evidence
42:23 – Repurposed Medications: Ivermectin
- Dr. Goodyear has used ivermectin in oncology since 2017
- Ivermectin won Nobel Prize in Medicine in 2015
- In vitro and in vivo studies show parallel impacts on pathways used by both parasites and cancer
- Safe medication when used appropriately
43:39 – Parasites and Cancer: Truth vs. Fiction
- What parasites and cancer have in common:
- Both grow and spread
- Both require specific environments
- Both evade immune system
- Both can kill the host
- Critical distinction: This does NOT mean cancer IS a parasite
- Three parasitic infections classified as Class 1 carcinogens by WHO (e.g., liver flukes causing cholangiocarcinoma)
- Parasites can cause cancer, but not all cancers are parasites
46:02 – Effectiveness of Repurposed Drugs
- Ivermectin and mebendazole have anti-cancer properties
- Not a panacea or cure-all
- Example: Stage 4 prostate cancer patient achieved remission with ivermectin alone (rare case)
- These drugs target pathways cancer uses (glutamine pathway, nuclear factor kappa beta)
- Mebendazole has human studies showing it can improve chemotherapy and immunotherapy outcomes
- Ivermectin and fenbendazole lack these human studies
50:00 – Complexity of Cancer
- Cancer is NOT caused by:
- One stressful event
- One parasitic infection
- One virus
- One bacterial infection
- One toxin
- One metabolic dysfunction
- Reality: Cancer results from ALL of these layered together
- Includes epigenetic transgenerational inheritance of pathology
- Different environmental exposures than our grandparents faced
53:49 – The Cancer Vault Resource
- Available at prescribe.com
- AI-generated tool containing Dr. Goodyear’s research studies
- Categorized with his comments
- Allows patients to see supporting research and dive deeper into topics
- Houses podcasts, blog posts, videos, and social media content
55:00 – Beverly Hills vs. Cabo Locations
- Beverly Hills office: Performs fecal transplants and patient consultations
- Cabo, Mexico: Performs innovative treatments not yet approved in US
- Phase 2 FDA clinical trial for prostate cancer (FDA fast-tracked due to Phase 1 results):
- 53% of metastatic castrate-resistant prostate cancer patients showed no evidence of disease at one year
- Uses intratumoral cryotherapy and immunotherapy
- Mexico’s right-to-treat laws allow innovation ahead of US regulatory processes
- Hospitals in Cabo described as pristine with excellent staff
- Dr. Goodyear lives in Cabo with his family
1:00:13 – Closing
- Final remarks and acknowledgments
- Information about the show and disclaimer
Important Resources Mentioned:
- prescribe.com – Dr. Goodyear’s website with Cancer Vault research database
- Williams Cancer Institute – Beverly Hills and Cabo San Lucas locations
- Phase 2 prostate cancer clinical trial (recruiting in US)
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