Can ketone supplements reduce essential tremors—without drugs or surgery?
In this episode of Pod of Inquiry, we sit down with Maria Watson, CEO of Approved Medical Solutions, to discuss her remarkable experience living with essential tremor for more than 25 years. ( Can Ketones Stop Essential Tremors )
After trying countless approaches, Maria made an unexpected discovery: a precise dose of exogenous ketones dramatically reduced her tremors in just 40 minutes. What began as a workout supplement soon became the focus of a pilot study, where 95% of participants reported noticeable tremor reduction after a single dose.
Now, Maria and her team are launching a larger clinical study to further investigate whether ketone supplementation could offer a new approach for people living with essential tremor.
In This Episode you’ll discover:
- Why ketones may provide a more efficient fuel source for the brain than glucose in certain conditions
- How nitric oxide and improved blood flow may enhance ketone delivery to the central nervous system
- The surprising connection between essential tremor, nerve entrapment, and cellular energy
- Why Dr. Barrett believes similar bioenergetic principles apply in peripheral nerve surgery
- What Maria experienced after maintaining low nutritional ketosis for more than a year
- The importance of supplement quality and the challenges within the nutraceutical industry
If you or someone you know struggles with essential tremor, this conversation offers an intriguing look at an emerging area of research.
📌 Interested in the Essential Tremor Study?
The study is free to participate in. Researchers are currently seeking adults with essential tremor (not Parkinson’s disease) who are not taking tremor medications and are willing to complete a simple three-day protocol.
➡️ Learn more and find enrollment details at PodofInquiry.com.
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Author Biography
Maria Watson, CEO — Approved Medical Solutions
Maria shares over 32 years of experience in the supplement formulation and manufacturing industry.
In 1987 she lost her 3-year-old son Joshua to a drunk driver. For three years, I suffered from severe depression and was overly medicated.
On 2/11/91, she was introduced to an amino acid formulation and got her life back. The passion for saving people from depression in my son’s honor had begun.
Soon after joining the company that made that formula-it stopped working! It was in 1994 that she went into formulation and manufacturing so she would always be able to control the quality of my products.
Before recently starting Approved Medical Solutions, she and her husband owned Vitamin Research Products (VRP), which included the highly respected medical brand Complementary Prescriptions (CP). Over 1100 formulas were manufactured in our state-of-the-art 55,000-square-foot cGMP facility. Although thy sold the brands in 2010, her retirement was short-lived as her passion for health remained strong.
Throughout this deeply rewarding journey in the Health and Wellness industry, she had the privilege of working with some amazing experts–many of the who’s-who in medicine and science: John Lee, MD, Ward Dean, MD, Frank Shallenberger, MD, Guy Abraham, MD, David Brownstein, MD, Mitchell Ghen, MD, Mitchell Fleisher, MD, Nathan Bryan, Ph.D., Beth Shirley, Rph CCN.
Show Notes from this episode
Episode Overview
Maria Watson, a 25-year essential tremor sufferer and founder of Approved Medical Solutions, joins Dr. Barrett to describe how a precise dose of exogenous ketones (24g on a glycerol carrier, no butanediol) stopped her tremors within 40 minutes — a discovery she made accidentally while studying metabolic performance. Her informal pilot study showed 95% of participants experienced measurable tremor reduction. A formal study is now enrolling (FREE, no obligation). The conversation weaves Maria’s personal story with Dr. Barrett’s bioenergetic framework from peripheral nerve surgery, illuminating why ketones may rescue energy-deprived neural circuits in both the peripheral and central nervous systems.
- [0:00] Introduction — Dr. Barrett introduces Maria Watson & Approved Medical Solutions
- [1:30] Maria’s background: building four supplement brands rooted in quality and efficacy
- [6:50] Maria’s origin story: personal tragedy, amino acids, and a life-changing discovery
- [10:50] The corrupt supplement industry — why potency and sourcing matter
- [13:40] Discovering exogenous ketones: metabolic flexibility and workout performance
- [19:36] The accidental discovery — 24g ketones and tremor relief in 40 minutes
- [22:30] Pilot study design: the Parkinson spiral, nitric oxide, and 95% positive outcomes
- [24:00] Barrett connects bioenergetics: peripheral nerve entrapment vs. essential tremor
- [26:11] Tremor demographics — 10 million+ affected, increasing in younger populations
- [29:00] The cumulative effect — why sustained ketosis may train the brain
- [32:12] The formal study: enrollment criteria, protocol, and how to join
- [36:06] Study dosing protocol — nitric oxide, ketone timing, and vasodilatation
- [40:04] Inclusion/exclusion criteria and the breadth of potential neurological applications
- [43:37] Publishing challenges and peer-review friction in medical research
- [45:19] Beyond tremor: ketones, mood, and metabolic wellbeing
- [46:26] Barrett’s ketone explainer — the body as a hybrid car
Key Topics & Concepts
- Essential tremor: prevalence, demographics, and unmet need
- Exogenous ketones vs. ketone salts vs. keto esters — what’s the difference?
- The role of ketone ester on glycerol (no butanediol) and why it matters
- Nitric oxide synergy: vasodilation as a delivery mechanism for brain ketosis
- Why 20–25g of ketones may cross the threshold for neurological effect
- The bioenergetic model of tremor: focal energy deprivation in neural circuits
- Parallel to peripheral nerve surgery: D5W hydrodissection and energy rescue
- Cumulative effect — does the brain ‘learn’ to stay in low ketosis?
- Approved Medical Solutions pilot study: design, results (95%), and formal enrollment
- Study enrollment criteria: presence of tremor, not Parkinson’s-diagnosed, no tremor meds
- The supplement industry’s quality problem: potency, sourcing, and label integrity
Study Enrollment — Essential Tremor
Maria’s formal ketone + essential tremor study is actively recruiting participants. Participation is completely FREE with no obligation.
Inclusion criteria:
- Presence of any tremor (mild to severe)
- Not diagnosed with Parkinson’s disease
- Not currently on tremor medications
Protocol (3 days):
- Sign your name (baseline)
- Take nitric oxide supplement — wait 50 minutes
- Take 24g ketones (2 oz concentrate) — wait 40 minutes
- Sign your name again (outcome measure)
Enrollment link: bioinsights.com/study
All study materials (ketones, nitric oxide, test strips) are provided at no charge.
Resources & Links
- Study enrollment link: com/study
- Approved Medical Solutions: com
- Keto Mojo (research section): keto-mojo.com
- ValAsta Astaxanthin (sponsor): net — code: POI5 (5% off)
- BBack Footwear (sponsor): us — code: POI10 (10% off)
Pod of Inquiry website: PodofInquiry.com
Sponsors Of The Episode
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Approved Medical Solutions
Your source for Oxalate free Nitric Oxide Supplementation
Non-licensed patients can use code “sbarrett” for a 10% discount.
Licensed practitioners can access the discounts by registering and when at checkout put “podofinquiry” (no space and not case sensitive) in the coupon section.
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Nitric Oxide
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